Activation-associated secreted proteins are the most abundant antigens in a host protective fraction from Ostertagia ostertagi.
نویسندگان
چکیده
P. Geldhof a,∗, I. Vercauteren a, K. Gevaert b, A. Staes b, D.P. Knox c, J. Vandekerckhove b, J. Vercruysse a, E. Claerebout a a Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke B9820, Belgium b Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, Merelbeke, Belgium c Moredun Research Institute, Edinburgh EH26 0PZ, Scotland, UK
منابع مشابه
Vaccine testing of a recombinant activation-associated secreted protein (ASP1) from Ostertagia ostertagi.
Previous vaccination trials against the economically important cattle parasite Ostertagia ostertagi have indicated the protective capacity of activation-associated secreted proteins (ASPs). The further development of these antigens into a commercial vaccine will require their recombinant expression. The aim of the current study was to clone and express Oo-asp1 in a baculovirus expression system...
متن کاملHost protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response
The mucus-dwelling parasite Ostertagia ostertagi is one of the most important gastrointestinal nematodes in cattle. Our group has previously demonstrated the protective capacity of a vaccine against this parasite based on a native activation-associated secreted protein ASP1 (nASP) in combination with the saponin adjuvant QuilA. The aim of the current study was to analyse the effect of both anti...
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Helminth parasitism of food and dairy animals has been responsible for significant economic losses throughout the world. Although a number of helminth parasites affect ruminants, but Haemonchus contortus and Ostertagia ostertagi are of paramount importance as they affect their hosts in a number of ways and often result in their death. The aim of the present trial was to do a comparative analysi...
متن کاملGender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi.
Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/PR-1/Sc7 family. Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or N-terminal domain of the two-domain ASP. The function of these proteins is still unclear, but a r...
متن کاملLocalized complement activation in the development of protective immunity against Ostertagia ostertagi infections in cattle.
The abomasal nematode Ostertagia ostertagi is a major causal agent contributing to production inefficiencies in the cattle industry in temperate regions of the world. Protective immunity to infections develops very slowly and resistance to reinfection manifests only after prolonged exposure. Mechanisms underlying the development of protective immunity remain largely unexplored. Immune animals, ...
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ورودعنوان ژورنال:
- Molecular and biochemical parasitology
دوره 128 1 شماره
صفحات -
تاریخ انتشار 2003